Saccharomyces cerevisiae (S288c)

SIR2

MAR1, NAD-dependent histone deacetylase SIR2, L000001895, YDL042C
Conserved NAD+ dependent histone deacetylase of the Sirtuin family; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication; functions as a regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy; SIR2 has a paralog, HST1, that arose from the whole genome duplication
UBI
PHO

External Database Linkouts

SGD | Entrez Gene | RefSeq | UniprotKB | PhosphoGRID
Download 498 Published Interactions For This Protein
32017
559292
  • Stats & Options
Switch View:
  • Interactors (298)
  • Interactions (498)
  • Network
  • PTM Sites (5)