Saccharomyces cerevisiae (S288c)


histone demethylase GIS1, L000003351, YDR096W
Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication

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SGD | Entrez Gene | RefSeq | UniprotKB | PhosphoGRID
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  • Interactors (82)
  • Interactions (111)
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  • PTM Sites (15)