Saccharomyces cerevisiae

SIR4

STE9, ASD1, UTH2, YDR227W

Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan

GO Process: 3 Terms

GO Function: 4 Terms

GO Component: 3 Terms

Gene Ontology Biological Process

chromatin silencing [TAS]

double-strand break repair via nonhomologous end joining [IDA]

loss of chromatin silencing during replicative cell aging [IDA]

Gene Ontology Molecular Function

double-stranded DNA binding [IDA]
histone binding [TAS]
nucleosome binding [IDA]
structural constituent of chromatin [TAS]

Gene Ontology Cellular Component

chromatin silencing complex [IDA]

nuclear telomere cap complex [IDA]

nuclear telomeric heterochromatin [IDA]

External Database Linkouts

Download 69 Associations For This Protein

32279

4932

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Summary
Table

Interaction Summary