Saccharomyces cerevisiae (S288c)

RSP5

MDP1, MUT2, NPI1, SMM1, UBY1, NEDD4 family E3 ubiquitin-protein ligase, L000001054, L000001779, L000001220, YER125W
E3 ubiquitin ligase of NEDD4 family; regulates many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, ribosome stability; mutant tolerates aneuploidy; autoubiquitinates; ubiquitinates Sec23p and Sna3p; deubiquitinated by Ubp2p; activity regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; human homolog implicated in Liddle syndrome
UBI
PHO
NEDD
SUMO
GO Process (33)
GO Function (3)
GO Component (9)

Gene Ontology Biological Process

External Database Linkouts

SGD | Entrez Gene | RefSeq | UniprotKB | PhosphoGRID
Download 751 Published Interactions For This Protein
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  • Interactors (408)
  • Interactions (751)
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  • PTM Sites (12)