Caenorhabditis elegans
AIR-2
CELE_B0207.4, let-603, stu-7, cyk-6, B0207.4
air-2 encodes an aurora/Ipl1-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies.
GO Process (16)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- chromosome condensation [IMP]
- chromosome segregation [IMP]
- cytokinesis, completion of separation [IMP]
- embryo development ending in birth or egg hatching [IMP]
- establishment of protein localization [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- meiotic nuclear division [IMP]
- mitotic nuclear division [IMP]
- mitotic spindle midzone assembly [IMP]
- mitotic spindle organization [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of actomyosin contractile ring contraction [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 18
- Interactions 31
- Network