Caenorhabditis elegans
WRT-4
CELE_ZK678.5, ZK678.5
wrt-4 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, an short region of low-complexity sequence, and a Hint/Hog domain; WRT-4 is expressed strongly in hypodermal syncytia hyp6-hyp10 from 3-fold embryos to adults; the Hint/Hog domain is predicted to cut WRT-4 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-4 is weakly required for normal molting; WRT-4 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
GO Process (8)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- cell-cell signaling [NAS]
- embryo development ending in birth or egg hatching [IMP]
- locomotion [IMP]
- molting cycle, collagen and cuticulin-based cuticle [IMP]
- negative regulation of vulval development [IMP]
- positive regulation of multicellular organism growth [IMP]
- protein autoprocessing [NAS]
- segment polarity determination [NAS]
Gene Ontology Cellular Component
Download Curated Data for this Protein
46556
6239
Switch View:
- Interactors 3
- Interactions 3
- Network