Caenorhabditis elegans
GSTO-1
CELE_C29E4.7, C29E4.7
gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site.
GO Process (9)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
- cellular response to extracellular stimulus [IDA]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- oviposition [IMP]
- oxidation-reduction process [IDA]
- protein glutathionylation [IDA]
- response to oxidative stress [IDA, IMP]
- response to superoxide [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
47837
6239
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- Interactors 2
- Interactions 2
- Network