Saccharomyces cerevisiae (S288c)

CDC45

SLD4, L000003380, YLR103C
DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
UBI
PHO

External Database Linkouts

SGD | Entrez Gene | RefSeq | UniprotKB
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  • PTM Sites (3)