Saccharomyces cerevisiae (S288c)

SAN1

ubiquitin-protein ligase SAN1, L000001800, YDR143C
Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins
Download Curated Data for this Protein
32197
559292
Switch View:
  • Interactors 211
  • Interactions 265
  • Network
  • PTM Sites 12