Caenorhabditis elegans

ACBP-1

CELE_C44E4.6, C44E4.6
acbp-1 encodes a highly conserved protein containing a functional acyl-CoA-binding binding domain orthologous to human DBI (Diazepam Binding inhibitor) (OMIM: 125950) required for protein stability and ligand binding; acyl-CoA proteins are required for lipid droplet morphology and lipid storage function; acbp-1 mutants have reduced triglycerides, aberrant lipid droplet morphology and number in the intestine; mutants contain approximately 70% fewer but 3.8 times enlarged than that of the average lipid droplet; loss of ACBP-1 results in increased lipid chain unsaturation by 1.25 times; disruption of ACBP-1 function significantly reduces worm life span from 14 to 9 days; ACBP-1::GFP is predominantly expressed in intestine of L4 larvae.
Download Curated Data for this Protein
37535
6239
Switch View:
  • Interactors 43
  • Interactions 43
  • Network