Caenorhabditis elegans

PQN-85

CELE_Y43H11AL.3, Y43H11AL.3
pqn-85 encodes an ortholog of budding yeast Scc2p, Drosophila NIPPED-B, and human NIPBL (OMIM:608667, mutated in Cornelia de Lange syndrome) that is required for resistance to double-stranded DNA breakage; PQN-85 is also required, with MAU-2 and SCC-3, for normal chromosome segregation and embryonic viability; pqn-85(RNAi) induces hypersensitivity to double-stranded breaks in DNA (manifested by abnormal sterility induced by ionizing radiation, cisplatin, or camptothecin); pqn-85(RNAi) of early embryos produces lagging of anaphase chromosomes and 100% embryonic lethality; pqn-85(RNAi) is phenotypically enhanced by joint RNAi with mau-2, and joint pqn-85/scc-3(RNAi) grossly deranges chromosomal segregation in early embryos; by orthology with NIPPED-B, PQN-85 might also enable regulatory interactions between promoters and distant enhancers by antagonizing SCC-3.
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