Caenorhabditis elegans

SDHB-1

CELE_F42A8.2, tag-55, F42A8.2
sdhb-1 encodes the C. elegans ortholog of human succinate dehydrogenase subunit B (SDHB; OMIM:185470, mutations lead to extraadrenal pheochromocytoma) which contains several iron-sulfur (Fe-S) clusters and functions to transfer electrons from the A (SDHA) subunit to the membrane-associated C (SDHC) subunit; RNAi screens indicate that sdhb-1 activity is essential for embryonic and larval development, as well as for normal brood sizes, body morphology, osmoregulation, and growth rate; in addition, transgenic animals expressing SDHB-1 variants at the conserved Pro211 residue exhibit various phenotypes, including hypersensitivity to oxidative stress, reduced life span, impaired respiration and excess superoxide production; sdhb-1 is widely expressed in larvae and adults and SDHB-1 localizes to mitochondria.
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