Caenorhabditis elegans

TPI-1

CELE_Y17G7B.7, TPI, Y17G7B.7
tpi-1 encodes a putative triosephosphate isomerase orthologous to human TPI1 (OMIM:190450, mutated in TPI deficiency) and Drosophila WASTED AWAY; loss of tpi-1 activity via RNAi results in increased resistance to exogenous oxidants and shortening of natural adult lifespan, both presumably due to alterations in the redox state of cells.
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  • Interactors 52
  • Interactions 52
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