Caenorhabditis elegans

GRK-2

CELE_W02B3.2, tag-161, W02B3.2
grk-2 encodes a serine/threonine protein kinase that is most closely related to G protein-coupled receptor (GPCR) kinases; in C. elegans, grk-2 activity is required in chemosensory neurons for normal calcium influx during chemosensation, but is not required for GPCR downregulation; in regulating chemosensation, GRK-2 likely acts upstream of the ODR-3/G alpha protein, as overexpression of ODR-3 can rescue abnormal avoidance behavior in grk-2 mutants; GRK-2 is broadly expressed in the adult nervous system, with expression beginning as early as the 20-30-cell stage of embryonic development and continuing into adulthood.
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