Caenorhabditis elegans
PAA-1
CELE_F48E8.5, F48E8.5
paa-1 encodes the sole C. elegans homolog of PR65, the structural subunit of protein phosphatase 2A (PP2A); paa-1 is an essential gene, required in RNAi assays for embryonic viability, fertility, and cuticular integrity; PAA-1 protein physically interacts with LET-92, the PP2A catalytic subunit, and with RSA-1, a PP2A regulatory subunit; PAA-1 also physically interacts with SMG-5; PAA-1 localizes to centrosomes, the mitotic spindle, P granules, and the nuclear envelope; PAA-1 levels at the centrosome are decreased in rsa-1 mutant animals.
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- RNA interference [IMP]
- apoptotic process [IMP]
- cell division [IMP]
- cell migration [IMP]
- embryo development ending in birth or egg hatching [IGI, IMP]
- gonad development [IMP]
- locomotion [IMP]
- mitotic nuclear division [IMP]
- mitotic spindle organization [IMP]
- nematode larval development [IMP]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
- secretion by cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
40979
6239
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- Interactors 16
- Interactions 19
- Network