Caenorhabditis elegans
CUL-1
CELE_D2045.6, lin-19, D2045.6
cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10).
GO Process (14)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
- apoptotic process [IMP]
- cell migration [IMP]
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- gonad development [IMP]
- mitotic nuclear division [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IMP]
- nematode larval development [IMP]
- positive regulation of apoptotic process [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of cell size [IMP]
- reproduction [IMP]
Download Curated Data for this Protein
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- Interactors 36
- Interactions 56
- Network