Caenorhabditis elegans
LET-70
CELE_M7.1, ubc-2, M7.1
let-70 encodes a class I E2 ubiquitin conjugating enzyme; let-70 was identified in screens for essential genes and phenotypic analyses indicate that loss of let-70 activity results in embryonic and larval lethality with defects in sarcomere assembly; purified LET-70 can stimulate the self-ubiquitylation activities of CHN-1 and UFD-2, E4 ubiquitin conjugation factors and, in addition, can stimulate the CHN-1- and UFD-2-dependent multiubiquitylation of UNC-45, a myosin-directed chaperone; in this manner, LET-70 may regulate UNC-45 degradation and myosin assembly; RNA blot analyses and a let-70-lacZ reporter fusion reveal that let-70 is abundantly expressed at all stages of development, including the dauer larval stage; strong staining is observed in most somatic tissues until adult stages, when expression generally becomes restricted to the nervous system.
GO Process (12)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
- apoptotic process [IMP]
- cell migration [IMP]
- embryo development ending in birth or egg hatching [IMP]
- germ cell development [IMP]
- gonad development [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- meiotic nuclear division [IMP]
- nematode larval development [IMP]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- reproduction [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
43106
6239
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- Interactors 25
- Interactions 27
- Network