Caenorhabditis elegans

FIGL-1

CELE_F32D1.1, F32D1.1
figl-1 encodes an homolog of human SPASTIN (OMIM:604277, mutated in spastic paraplegia), FIDGETIN (OMIM:605295, mutated in fidget mice), and FIDGETIN-LIKE-1, and of Drosophila SPASTIN; recombinant FIGL-1 protein has N-ethylmaleimide-sensitive ATPase activity in vitro, which is strongly dependent on the C368 residue immediately C-terminal to its Walker A motif; figl-1 is required for persistence of the germline in RNAi assays.

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (9)
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