Caenorhabditis elegans
SAP-49
CELE_C08B11.5, C08B11.5
sap-49 encodes the C. elegans ortholog of mammalian SAP49, a component of the SF3b splicing factor, a U2 snRNP-associated protein complex; loss of sap-49 activity via RNAi results in embryonic lethality, a protruding vulva, reduced levels of gene expression (as assessed by a gfp reporter), and early onset of foci formation in strains expressing polyglutamine-YFP; SAP-49 exhibits sequence-specific RNA binding in vitro; sap-49 mRNA is expressed at all developmental stages, while a SAP-49::lacZ translational fusion protein is reportedly expressed in specific cells, including pharyngeal muscles, in larvae and adults.
GO Process (8)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
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606934
6239
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- Interactors 16
- Interactions 19
- Network