Act1, an NF-kappa B-activating protein.

Departments of Immunology and Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator. Act1 associates with and activates IkappaB kinase (IKK), leading to the liberation of NF-kappaB from its complex with IkappaB. Many signaling pathways that liberate NF-kappaB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-kappaB and JNK. Act1 fails to activate NF-kappaB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Carrier Proteins, Cell Line, DNA, Complementary, Enzyme Activation, Helix-Loop-Helix Motifs, Humans, Interleukin-1, JNK Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases, Molecular Sequence Data, NF-kappa B, Recombinant Proteins, Sequence Homology, Nucleic Acid, Trans-Activators, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Proc. Natl. Acad. Sci. U.S.A. Sep. 12, 2000; 97(19);10489-93 [PUBMED:10962024]
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