UHRF1
Gene Ontology Biological Process
- cell proliferation [TAS]
- histone monoubiquitination [IDA]
- histone ubiquitination [ISO]
- maintenance of DNA methylation [IMP, ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- protein autoubiquitination [ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- core promoter proximal region sequence-specific DNA binding [ISO]
- hemi-methylated DNA-binding [IDA, ISO]
- histone binding [ISO]
- identical protein binding [IPI]
- methyl-CpG binding [ISO]
- methylated histone binding [IDA, ISO]
- nucleosomal histone binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [ISO]
- core promoter proximal region sequence-specific DNA binding [ISO]
- hemi-methylated DNA-binding [IDA, ISO]
- histone binding [ISO]
- identical protein binding [IPI]
- methyl-CpG binding [ISO]
- methylated histone binding [IDA, ISO]
- nucleosomal histone binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
PARP1
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [ISO]
- DNA metabolic process [IMP]
- DNA repair [TAS]
- base-excision repair [IMP]
- cellular response to insulin stimulus [ISO]
- cellular response to superoxide [IDA]
- double-strand break repair [IGI, ISO]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein ADP-ribosylation [IBA, ISO]
- protein autoprocessing [ISO]
- protein poly-ADP-ribosylation [ISO]
- regulation of growth rate [IMP]
- signal transduction involved in regulation of gene expression [ISO]
- telomere maintenance [IMP]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Topoisomerase II regulates the maintenance of DNA methylation.
The maintenance of DNA methylation in nascent DNA is a critical event for numerous biological processes. Following DNA replication, DNMT1 is the key enzyme that strictly copies the methylation pattern from the parental strand to the nascent DNA. However, the mechanism underlying this highly specific event is not thoroughly understood. In this study, we identified topoisomerase IIα (TopoIIα) as a ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UHRF1 PARP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PARP1 UHRF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID