BAIT

HBP1

HMG-box transcription factor 1
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

RBL2

P130, Rb2
retinoblastoma-like 2
GO Process (2)
GO Function (1)
GO Component (5)

Gene Ontology Molecular Function

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A.

Lavender P, Vandel L, Bannister AJ, Kouzarides T

A yeast two-hybrid screen has identified HBP1 as a transcription factor capable of interacting with the pocket protein family. We show that HBP1 can interact with one of these, RB, both in vitro and in mammalian cells. Two distinct RB binding sites are present within HBP1--a high affinity binding site, mediated by an LXCXE motif and a separate low affinity ... [more]

Oncogene Jun. 05, 1997; 14(22);2721-8 [Pubmed: 9178770]

Throughput

  • Low Throughput

Curated By

  • BioGRID