BAIT
PEX7
PBD9B, PTS2R, RCDP1, RD, RP11-55K22.6
peroxisomal biogenesis factor 7
GO Process (3)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PHYH
LN1, LNAP1, PAHX, PHYH1, RD, RP11-24J20.1
phytanoyl-CoA 2-hydroxylase
GO Process (5)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of PAHX, a Refsum disease gene.
Refsum disease is an autosomal recessive disorder characterized by retinitis pigmentosa, peripheral polyneuropathy, cerebellar ataxia and increased cerebrospinal fluid protein. Biochemically, the disorder is defined by two related properties: pronounced accumulation of phytanic acid and selective loss of the peroxisomal dioxygenase required for alpha-hydroxylation of phytanoyl-CoA2. Decreased phytanic-acid oxidation is also observed in human cells lacking PEX7, the receptor for ... [more]
Nat. Genet. Oct. 01, 1997; 17(2);185-9 [Pubmed: 9326939]
Throughput
- Low Throughput
Curated By
- BioGRID