BAIT

HAND2

DHAND2, Hed, Thing2, bHLHa26, dHand
heart and neural crest derivatives expressed 2
GO Process (18)
GO Function (10)
GO Component (3)
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer.

Dai YS, Cserjesi P

HAND2 (dHAND) is a basic helix-loop-helix (bHLH) transcription factor expressed in numerous tissues during development including the heart, limbs, and a subset of neural crest derivatives. Functional analysis has shown that HAND2 is involved in development of the branchial arches, heart, limb, vasculature, and nervous system. Although it is essential for development of numerous tissues, little is known about its ... [more]

J. Biol. Chem. Apr. 12, 2002; 277(15);12604-12 [Pubmed: 11812799]

Throughput

  • Low Throughput

Curated By

  • BioGRID