VEGFA
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- activation of protein kinase activity [IDA]
- angiogenesis [IDA]
- artery morphogenesis [ISS]
- basophil chemotaxis [IDA]
- blood coagulation [TAS]
- branching morphogenesis of an epithelial tube [ISS]
- camera-type eye morphogenesis [ISS]
- cardiac muscle fiber development [ISS]
- cardiac vascular smooth muscle cell development [ISS]
- cell maturation [ISS]
- cell migration involved in sprouting angiogenesis [IDA]
- cellular response to hypoxia [IDA, TAS]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- commissural neuron axon guidance [ISS]
- coronary artery morphogenesis [ISS]
- coronary vein morphogenesis [ISS]
- dopaminergic neuron differentiation [ISS]
- endothelial cell chemotaxis [IDA]
- epithelial cell differentiation [ISS]
- eye photoreceptor cell development [ISS]
- growth [ISS]
- heart morphogenesis [ISS]
- in utero embryonic development [ISS]
- induction of positive chemotaxis [IDA, NAS]
- kidney development [ISS]
- lactation [ISS]
- lung development [ISS]
- lymph vessel morphogenesis [ISS]
- macrophage differentiation [IDA]
- mammary gland alveolus development [ISS]
- mesoderm development [ISS]
- monocyte differentiation [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nervous system development [TAS]
- outflow tract morphogenesis [ISS]
- ovarian follicle development [ISS]
- patterning of blood vessels [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive chemotaxis [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell migration involved in sprouting angiogenesis [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cellular component movement [IDA]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA, ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of histone deacetylase activity [IDA]
- positive regulation of leukocyte migration [TAS]
- positive regulation of mast cell chemotaxis [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine autophosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein kinase C signaling [IDA]
- positive regulation of protein kinase D signaling [IDA]
- positive regulation of protein localization to early endosome [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of vascular permeability [IDA]
- post-embryonic camera-type eye development [ISS]
- primitive erythrocyte differentiation [ISS]
- regulation of cGMP metabolic process [IDA]
- regulation of cell shape [IDA]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- surfactant homeostasis [ISS]
- tube formation [IDA]
- vascular endothelial growth factor receptor signaling pathway [IDA, TAS]
- vascular endothelial growth factor signaling pathway [IDA]
- vasculogenesis [TAS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
Gene Ontology Cellular Component
FLT1
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cell migration [IMP]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- embryonic morphogenesis [ISS]
- monocyte chemotaxis [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phospholipase C activity [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein autophosphorylation [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IMP, TAS]
- vascular endothelial growth factor receptor-1 signaling pathway [IDA]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
Gene Ontology Molecular Function- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
- VEGF-A-activated receptor activity [IDA]
- VEGF-B-activated receptor activity [IDA]
- growth factor binding [IPI]
- placental growth factor-activated receptor activity [IDA]
- protein binding [IPI]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- vascular endothelial growth factor-activated receptor activity [IDA, IMP]
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
Despite the advent of biological therapies for the treatment of rheumatoid arthritis, there is a compelling need to develop alternative therapeutic targets for nonresponders to existing treatments. Soluble receptors occur naturally in vivo, such as the splice variant of the cell surface receptor for vascular endothelial growth factor (VEGF)--a key regulator of angiogenesis in rheumatoid arthritis. Bioinformatics analyses predict that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VEGFA FLT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2220275 | |
| FLT1 VEGFA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9997 | BioGRID | 3300656 | |
| VEGFA FLT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3086439 | |
| VEGFA FLT1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| FLT1 VEGFA | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID