BAIT

IL2RG

CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1
interleukin 2 receptor, gamma
UBI

External Database Linkouts

BioGRID ORCS | VEGA | OMIM | HGNC | Entrez Gene | RefSeq | UniprotKB | Ensembl | HPRD
Homo sapiens

PREY

CAPNS1

CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1
calpain, small subunit 1
UBI

External Database Linkouts

BioGRID ORCS | OMIM | VEGA | HGNC | Entrez Gene | RefSeq | UniprotKB | Ensembl | HPRD
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain.

Noguchi M, Sarin A, Aman MJ, Nakajima H, Shores EW, Henkart PA, Leonard WJ

The small subunit of calpain, a calcium-dependent cysteine protease, was found to interact with the cytoplasmic domain of the common cytokine receptor gamma chain (gammac) in a yeast two-hybrid interaction trap assay. This interaction was functional as demonstrated by the ability of calpain to cleave in vitro-translated wild-type gammac, but not gammac containing a mutation in the PEST (proline, glutamate, ... [more]

Proc. Natl. Acad. Sci. U.S.A. Oct. 14, 1997; 94(21);11534-9 [Pubmed: 9326644]

Throughput

  • Low Throughput

Curated By

  • BioGRID