BAIT

SFRP2

AI851596, Sdf5
secreted frizzled-related protein 2
GO Process (60)
GO Function (5)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Mus musculus
PREY

WG

Br, CG4889, DWint-1, DWnt-1, Dint-1, Dm Wg, Dm-1, Dmel\CG4889, Gla, I, Sp, WNT, Wnt-1, Wnt/Wg, Wnt1, dWnt, fg, int-1, l(2)02657, l(2)rO727, l(2)wg, spd, wgl, Dmel_CG4889
wingless
GO Process (85)
GO Function (8)
GO Component (12)

Gene Ontology Biological Process

Drosophila melanogaster

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

Rattner A, Hsieh JC, Smallwood PM, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J

This paper describes the identification of a new family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the frizzled family of transmembrane receptors. The secreted frizzled-related proteins (sFRPs) are approximately 30 kDa in size, and each contains a putative signal sequence, a frizzled-like cysteine-rich domain, and a conserved hydrophilic carboxy-terminal domain. The ... [more]

Proc. Natl. Acad. Sci. U.S.A. Apr. 01, 1997; 94(7);2859-63 [Pubmed: 9096311]

Throughput

  • Low Throughput

Additional Notes

  • Drosophila Wingless labels mouse sFRP-2 and -3 expressed on the surface of human 293 cells.

Curated By

  • BioGRID