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NP_037379

serine protease HTRA2, mitochondrial isoform 1 preproprotein

Length: 458

1
MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV
51
TYGTPSLWAR LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG
101
TRSRAWLAVA LGAGGAVLLL LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI
151
ADVVEKTAPA VVYIEILDRH PFLGREVPIS NGSGFVVAAD GLIVTNAHVV
201
ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL PTLPLGRSAD
251
VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA
301
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS
351
SSGISGSQRR YIGVMMLTLS PSILAELQLR EPSFPDVQHG VLIHKVILGS
401
PAHRAGLRPG DVILAIGEQM VQNAEDVYEA VRTQSQLAVQ IRRGRETLTL
451
YVTPEVTE

Location	PTM	Residue	Source(s)	Note(s)
237	Ubiquitination	K	Beltrao P (2012)	-
			Povlsen LK (2012)	-
			Renaudin X (2014)	-
			Rose CM (2016)	-
			Stukalov A (2021)	-
			Udeshi ND (2012)	-
			Wagner SA (2011)	-
			Xu G (2010) [show 3 more ]	-
348	Ubiquitination	K	Rose CM (2016)	-
348	Ubiquitination	K	Stes E (2014)	-
395	Ubiquitination	K	Beltrao P (2012)	-
395	Ubiquitination	K	Wagner SA (2011)	-

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NP_659540

serine protease HTRA2, mitochondrial isoform 2

Length: 361

1
MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV
51
TYGTPSLWAR LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG
101
TRSRAWLAVA LGAGGAVLLL LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI
151
ADVVEKTAPA VVYIEILDRH PFLGREVPIS NGSGFVVAAD GLIVTNAHVV
201
ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKFGN SGGPLVNLDG
251
EVIGVNTMKV TAGISFAIPS DRLREFLHRG EKKNSSSGIS GSQRRYIGVM
301
MLTLSPRAGL RPGDVILAIG EQMVQNAEDV YEAVRTQSQL AVQIRRGRET
351
LTLYVTPEVT E

Location	PTM	Residue	Source(s)	Note(s)
283	Ubiquitination	K	Rose CM (2016)	-
283	Ubiquitination	K	Stes E (2014)	-

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NP_001308656

serine protease HTRA2, mitochondrial isoform 3 preproprotein

Length: 436

1
MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV
51
TYGTPSLWAR LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG
101
TRSRAWLAVA LGAGGAVLLL LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI
151
ADVVEKTAPA VVYIEILDRH PFLGREVPIS NGSGFVVAAD GLIVTNAHVV
201
ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL PTLPLGRSAD
251
VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA
301
IDFGNSGGPL VNLARELGAV SLQDGEVIGV NTMKVTAGIS FAIPSDRLRE
351
FLHRGEKKNS SSGISGSQRR YIGVMMLTLS PRAGLRPGDV ILAIGEQMVQ
401
NAEDVYEAVR TQSQLAVQIR RGRETLTLYV TPEVTE

Location	PTM	Residue	Source(s)	Note(s)
237	Ubiquitination	K	Beltrao P (2012)	-
			Povlsen LK (2012)	-
			Renaudin X (2014)	-
			Rose CM (2016)	-
			Stukalov A (2021)	-
			Udeshi ND (2012)	-
			Wagner SA (2011)	-
			Xu G (2010) [show 3 more ]	-
358	Ubiquitination	K	Rose CM (2016)	-
358	Ubiquitination	K	Stes E (2014)	-

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NP_001308657

serine protease HTRA2, mitochondrial isoform 4 preproprotein

Length: 426

1
MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV
51
TYGTPSLWAR LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG
101
TRSRAWLAVA LGAGGAVLLL LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI
151
ADVVEKTAPA VVYIEILDRH PFLGREVPIS NGSGFVVAAD GLIVTNAHVV
201
ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL PTLPLGRSAD
251
VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA
301
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS
351
SSGISGSQRR YIGVMMLTLS PRAGLRPGDV ILAIGEQMVQ NAEDVYEAVR
401
TQSQLAVQIR RGRETLTLYV TPEVTE

Location	PTM	Residue	Source(s)	Note(s)
237	Ubiquitination	K	Beltrao P (2012)	-
			Povlsen LK (2012)	-
			Renaudin X (2014)	-
			Rose CM (2016)	-
			Stukalov A (2021)	-
			Udeshi ND (2012)	-
			Wagner SA (2011)	-
			Xu G (2010) [show 3 more ]	-
348	Ubiquitination	K	Rose CM (2016)	-
348	Ubiquitination	K	Stes E (2014)	-

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Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.

Location	PTM	Residue	Source(s)	Note(s)
-	Ubiquitination	K	Danielsen JM (2011)	eyJOT1RFUyI6WyJQdXRhdGl2ZSB1YmlxdWl0aW4gc3Vic3RyYXRlcyIsImV4b2dlbm91cyBleHByZXNzaW9uIG9mIGJhaXQiXSwiUkVMQVRJT05TSElQUyI6eyJVQkMiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzExMzE2NFwvc3VtbWFyeVwvaG9tby1zYXBpZW5zXC91YmMuaHRtbCcgYWx0PSdVQkMnPlVCQzxcL2E+PFwvc3Bhbj4ifX0=
			Kim JB (2013)	eyJSRUxBVElPTlNISVBTIjp7IlVCQyI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMTEzMTY0XC9zdW1tYXJ5XC9ob21vLXNhcGllbnNcL3ViYy5odG1sJyBhbHQ9J1VCQyc+VUJDPFwvYT48XC9zcGFuPiJ9fQ==
			Kim W (2011)	eyJOT1RFUyI6WyJMaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZXMiLCJDYW5kaWRhdGUgdWJpcXVpdGluIHN1YnN0cmF0ZXMgd2VyZSBpZGVudGlmaWVkIHVzaW5nIHViaXF1aXRpbiByZW1uYW50IGltbXVub2FmZmluaXR5IHByb2ZpbGluZy4iXSwiUkVMQVRJT05TSElQUyI6eyJVQkMiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzExMzE2NFwvc3VtbWFyeVwvaG9tby1zYXBpZW5zXC91YmMuaHRtbCcgYWx0PSdVQkMnPlVCQzxcL2E+PFwvc3Bhbj4ifX0=
			Povlsen LK (2012)	eyJOT1RFUyI6WyJMaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZS4iLCJleG9nZW5vdXMgZXhwcmVzc2lvbiBvZiBiYWl0Il0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+In19
			Renaudin X (2014)	eyJOT1RFUyI6WyJUYWJsZSBTMTsgUHJvdGVpbnMgYW5kIHBlcHRpZGVzIGlkZW50aWZpZWQgaW4gRkFOQ0MgYW5kIEZBTkNDLWNvcnJlY3RlZCBjZWxsIGxpbmVzIiwiVGFibGUgUzI7IFByb3RlaW5zIGFuZCBwZXB0aWRlcyBpZGVudGlmaWVkIGluIEZBTkNBIGFuZCBGQU5DQS1jb3JyZWN0ZWQgY2VsbCBsaW5lcyJdLCJSRUxBVElPTlNISVBTIjp7IlVCQyI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMTEzMTY0XC9zdW1tYXJ5XC9ob21vLXNhcGllbnNcL3ViYy5odG1sJyBhbHQ9J1VCQyc+VUJDPFwvYT48XC9zcGFuPiJ9fQ==
			Sekine K (2005)	eyJSRUxBVElPTlNISVBTIjp7IlVCQyI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMTEzMTY0XC9zdW1tYXJ5XC9ob21vLXNhcGllbnNcL3ViYy5odG1sJyBhbHQ9J1VCQyc+VUJDPFwvYT48XC9zcGFuPiJ9fQ==
			Stes E (2014)	eyJOT1RFUyI6WyJpbnRlcmFjdGlvbiBkZXRlY3RlZCBieSBDT0ZSQURJQyIsImxpa2VseSB1YmlxdWl0aW4gY29uanVnYXRlIl0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+In19
			Udeshi ND (2012)	eyJOT1RFUyI6WyJCeSBNUyBkZXRlY3Rpb24gb2YgYSBseXNpbmUgZGktZ2x5Y2luZSByZW1uYW50Il0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+In19
			Wagner SA (2011)	eyJOT1RFUyI6WyJMaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZXMiLCJDYW5kaWRhdGUgdWJpcXVpdGluIHN1YnN0cmF0ZXMgd2VyZSBpZGVudGlmaWVkIHVzaW5nIHViaXF1aXRpbiByZW1uYW50IGltbXVub2FmZmluaXR5IHByb2ZpbGluZy4iLCJleG9nZW5vdXMgZXhwcmVzc2lvbiBvZiBiYWl0Il0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+In19
			Xu G (2010) [show 5 more ]	eyJOT1RFUyI6WyJDYW5kaWRhdGUgdWJpcXVpdGluIHN1YnN0cmF0ZXMgd2VyZSBpZGVudGlmaWVkIHVzaW5nIHViaXF1aXRpbiByZW1uYW50IGltbXVub2FmZmluaXR5IHByb2ZpbGluZy4iLCJleG9nZW5vdXMgZXhwcmVzc2lvbiBvZiBiYWl0Il0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+In19

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
UBC	Conjugate	-	Ubiquitination	K	PTM	Danielsen JM (2011)
						Kim JB (2013)
						Kim W (2011)
						Povlsen LK (2012)
						Renaudin X (2014)
						Sekine K (2005)
						Stes E (2014)
						Udeshi ND (2012)
						Wagner SA (2011)
						Xu G (2010) [show 5 more ]