Homo sapiens
APOE
AD2, APO-E, LDLCQ5, LPG
apolipoprotein E
GO Process (68)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- N-methyl-D-aspartate receptor clustering [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IDA]
- cGMP-mediated signaling [IDA]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA, IMP]
- chylomicron remnant clearance [IMP]
- cytoskeleton organization [TAS]
- fatty acid homeostasis [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IDA]
- high-density lipoprotein particle remodeling [IGI]
- intracellular transport [TAS]
- lipoprotein metabolic process [TAS]
- long-chain fatty acid transport [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of beta-amyloid formation [IDA]
- negative regulation of blood coagulation [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cholesterol biosynthetic process [IDA]
- negative regulation of cholesterol efflux [IDA]
- negative regulation of dendritic spine development [IDA]
- negative regulation of dendritic spine maintenance [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of inflammatory response [IC]
- negative regulation of lipid biosynthetic process [IDA]
- negative regulation of lipid transport across blood brain barrier [IDA]
- negative regulation of neuron death [IDA]
- negative regulation of phospholipid efflux [IDA]
- negative regulation of platelet activation [IDA]
- negative regulation of postsynaptic membrane organization [IDA]
- negative regulation of presynaptic membrane organization [IDA]
- nitric oxide mediated signal transduction [IDA]
- phospholipid efflux [IDA]
- phototransduction, visible light [TAS]
- positive regulation of beta-amyloid formation [IDA]
- positive regulation of cGMP biosynthetic process [IDA]
- positive regulation of cholesterol efflux [IDA, IGI]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of dendritic spine development [IDA]
- positive regulation of dendritic spine maintenance [IDA]
- positive regulation of lipid biosynthetic process [IDA]
- positive regulation of lipid transport across blood brain barrier [IDA]
- positive regulation of low-density lipoprotein particle receptor catabolic process [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of neurofibrillary tangle assembly [IDA]
- positive regulation of neuron death [IDA]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phospholipid efflux [IDA]
- positive regulation of postsynaptic membrane organization [IDA]
- positive regulation of presynaptic membrane organization [IDA]
- protein import [IDA]
- receptor-mediated endocytosis [IDA]
- regulation of Cdc42 protein signal transduction [IDA]
- regulation of axon extension [TAS]
- regulation of beta-amyloid clearance [IDA]
- regulation of neuron death [IDA]
- regulation of neuronal synaptic plasticity [TAS]
- regulation of tau-protein kinase activity [IDA]
- response to reactive oxygen species [NAS]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission, cholinergic [TAS]
- triglyceride metabolic process [IDA, IMP]
- very-low-density lipoprotein particle clearance [IDA, IMP]
- very-low-density lipoprotein particle remodeling [IDA, IGI]
Gene Ontology Molecular Function- antioxidant activity [IDA]
- beta-amyloid binding [IDA]
- heparin binding [IDA]
- identical protein binding [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- metal chelating activity [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- tau protein binding [IPI]
- very-low-density lipoprotein particle receptor binding [IDA, IPI]
- antioxidant activity [IDA]
- beta-amyloid binding [IDA]
- heparin binding [IDA]
- identical protein binding [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- metal chelating activity [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- tau protein binding [IPI]
- very-low-density lipoprotein particle receptor binding [IDA, IPI]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- chylomicron [IDA]
- cytoplasm [NAS, TAS]
- dendrite [NAS]
- early endosome [TAS]
- endocytic vesicle lumen [TAS]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- intermediate-density lipoprotein particle [IDA]
- low-density lipoprotein particle [IDA]
- membrane [IDA]
- neuronal cell body [NAS]
- nucleus [IDA]
- plasma membrane [TAS]
- very-low-density lipoprotein particle [IDA]
- vesicle [IDA]
Download Curated Data for this Protein
106845
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- Interactors 156
- Interactions 195
- Chemical Interactions 9
- Network
- PTM Sites 11