BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis. If you're interested in helping to contribute to a new or existing curation project, we'd love to hear from you.


COVID-19 Coronavirus

The BioGRID COVID-19 Coronavirus Curation Project provides comprehensive datasets of curated interactions for the viral proteins encoded by SARS-CoV-2, as well as for the related coronaviruses SARS-CoV and MERS-CoV that cause Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), respectively. These datasets encompass all direct interactions between virally-encoded proteins and host cell proteins, as well as post-translational modifications and chemical interactions of viral proteins.

Proteins: 110 | Publications: 1,616 | Interactions: 44,298 | Chemical Interactions: 282 | Post-Translational Modifications: 156

Ubiquitin-Proteasome System

The covalent attachment of ubiquitin to substrate proteins by the UPS controls the stability, interactions, activity and/or localization of the proteome. The UPS governs most if not all cellular processes, including protein homeostasis (proteostasis), signal transduction, stress responses, DNA repair and replication, chromosome segregation, gene expression, vesicle trafficking and autophagy. UPS misregulation is implicated in many human diseases including cancer, neurodegeneration, metabolic disorders, infection and immunity.

Proteins: 1,586 | Publications: 24,237 | Interactions: 415,878 | Chemical Interactions: 3,271 | Post-Translational Modifications: 62,580

Fanconi Anemia

Fanconi anemia (FA) is a genomic instability syndrome that predisposes afflicted individuals to congenital abnormalities, bone marrow failure and cancer. The most common malignancies found in FA patients are acute myeloid leukemia as well as squamous cell carcinomas of the head, neck and female genitalia. We have identified key genes involved in Fanconi anemia and curated their corresponding molecular interactions from the scientific literature.

Proteins: 69 | Publications: 4,020 | Interactions: 32,439 | Chemical Interactions: 116 | Post-Translational Modifications: 4,530


Glioblastoma (GBM) is the most common malignant brain tumor that accounts for 15% of all primary brain tumors and 45% of primary malignant brain tumors. It has a poor prognosis of only 5% survival at 5 years with a median survival of 14-15 months. We have identified key proteins involved in Glioblastoma and curated their corresponding molecular interactions from the scientific literature.

Proteins: 198 | Publications: 7,121 | Interactions: 52,568 | Chemical Interactions: 1,004 | Post-Translational Modifications: 8,771


Autophagy is the general process whereby cellular components are engulfed in double-membrane vesicles and delivered to lysosomes for degradation and recycling of macromolecular constituents. Autophagy is implicated in a plethora of major disease states that span neurodegeneration, infection and immunity, cardio and pulmonary vascular disease, cancer and aging.

Proteins: 197 | Publications: 4,786 | Interactions: 53,652 | Chemical Interactions: 398 | Post-Translational Modifications: 7,461

Alzheimer's Disease

Alzheimer's Disease (AD) is tightly associated with the abnormal accumulation of amyloid beta peptide and microtubule-associated protein tau (MAPT) in the brain. Amyloid Beta forms amyloid plaques between neurons, whereas hyperphosphorylated tau proteins form twisted strands called neurofibrillary tangles (NFTs) within neurons, both of which represent key phenotypic characteristics of AD.

Proteins: 466 | Publications: 20,203 | Interactions: 180,156 | Chemical Interactions: 5,089 | Post-Translational Modifications: 23,388

S. cerevisiae Kinome

This BioGRID curation project is designed to allow exploration of the entire yeast kinome and its interactions, including genetic interactions and all mapped sites of protein phosphorylation. The S. cerevisiae kinome project page builds on a high-throughput mass spectrometric analysis of the protein interactors of all kinases, phosphatases and associated regulatory subunits in the budding yeast Saccharomyces cerevisiae.

Proteins: 260 | Publications: 5,653 | Interactions: 106,445 | Post-Translational Modifications: 3,861