Homo sapiens
TIRAP
BACTS1, Mal, MyD88-2, wyatt
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
GO Process (35)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- TIRAP-dependent toll-like receptor 4 signaling pathway [IDA]
- cell surface receptor signaling pathway [ISS]
- cellular response to bacterial lipopeptide [ISS]
- cellular response to lipoteichoic acid [ISS]
- defense response to Gram-positive bacterium [ISS]
- innate immune response [TAS]
- myeloid cell differentiation [ISS]
- negative regulation of growth of symbiont in host [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of chemokine (C-X-C motif) ligand 1 production [ISS]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-15 production [IDA]
- positive regulation of interleukin-6 biosynthetic process [IMP]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of protein homodimerization activity [IDA]
- positive regulation of toll-like receptor 2 signaling pathway [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [ISS]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of innate immune response [IC]
- regulation of interferon-beta production [ISS]
- response to lipopolysaccharide [IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
125325
9606
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- Interactors 44
- Interactions 91
- Network
- PTM Sites 1