Rattus norvegicus
ESR1
ER-alpha, Esr, RNESTROR
estrogen receptor 1
GO Process (46)
GO Function (19)
GO Component (11)
Gene Ontology Biological Process
- Sertoli cell development [IEP]
- Sertoli cell proliferation [IMP]
- androgen metabolic process [ISO]
- antral ovarian follicle growth [ISO]
- baculum development [IEP]
- cellular response to estradiol stimulus [IDA]
- cellular response to estrogen stimulus [ISO]
- decidualization [IEP]
- epithelial cell development [ISO]
- epithelial cell proliferation involved in mammary gland duct elongation [ISO]
- intracellular receptor signaling pathway [ISO]
- intracellular steroid hormone receptor signaling pathway [IDA]
- male gonad development [IEP, ISO]
- mammary gland alveolus development [ISO]
- mammary gland branching involved in pregnancy [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- negative regulation of gene expression [ISO]
- negative regulation of glucose import [IDA]
- negative regulation of neuron death [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO, ISS]
- negative regulation of smooth muscle cell proliferation [IMP]
- negative regulation of triglyceride metabolic process [IDA]
- osteoblast development [IEP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of epidermal growth factor receptor signaling pathway [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of nitric-oxide synthase activity [ISO, ISS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of retinoic acid receptor signaling pathway [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, TAS]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [ISO]
- prostate epithelial cord elongation [ISO]
- regulation of apoptotic process [ISO]
- regulation of branching involved in prostate gland morphogenesis [ISO]
- regulation of neuron apoptotic process [IDA]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to estradiol [IEP, ISO]
- response to estrogen [ISO]
- transcription from RNA polymerase II promoter [ISO]
- uterus development [ISO]
- vagina development [ISO]
Gene Ontology Molecular Function- DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO, ISS]
- core promoter sequence-specific DNA binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- estrogen receptor activity [IDA, TAS]
- estrogen response element binding [ISO]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- hormone binding [IDA, IMP]
- identical protein binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- steroid binding [IDA]
- steroid hormone receptor activity [IDA]
- transcription factor binding [ISO]
- type 1 metabotropic glutamate receptor binding [IPI]
- DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO, ISS]
- core promoter sequence-specific DNA binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- estrogen receptor activity [IDA, TAS]
- estrogen response element binding [ISO]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- hormone binding [IDA, IMP]
- identical protein binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- steroid binding [IDA]
- steroid hormone receptor activity [IDA]
- transcription factor binding [ISO]
- type 1 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
Download Curated Data for this Protein
247000
10116
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- Interactors 11
- Interactions 15
- Network