Rattus norvegicus
LRRK2
leucine-rich repeat kinase 2
GO Process (57)
GO Function (20)
GO Component (29)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- MAPK cascade [ISO]
- activation of MAPK activity [ISO]
- activation of MAPKK activity [ISO]
- cellular protein localization [ISS]
- cellular response to dopamine [ISO]
- cellular response to manganese ion [ISO]
- cellular response to organic cyclic compound [IEP]
- cellular response to oxidative stress [ISO]
- determination of adult lifespan [ISO]
- endocytosis [ISO]
- exploration behavior [ISO]
- intracellular distribution of mitochondria [ISO]
- intracellular signal transduction [ISS]
- locomotory exploration behavior [ISS]
- negative regulation of GTPase activity [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of peroxidase activity [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of protein processing [ISO]
- negative regulation of protein targeting to mitochondrion [ISO]
- negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [ISO]
- neuromuscular junction development [ISO]
- neuron death [ISO]
- neuron projection morphogenesis [ISO, ISS]
- olfactory bulb development [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of dopamine receptor signaling pathway [ISO]
- positive regulation of programmed cell death [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein autoubiquitination [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of branching morphogenesis of a nerve [ISO]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of dopamine receptor signaling pathway [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of kidney size [ISO]
- regulation of locomotion [ISO]
- regulation of membrane potential [ISO]
- regulation of mitochondrial depolarization [ISO]
- regulation of neuroblast proliferation [ISO]
- regulation of neuron death [ISO]
- regulation of neuron maturation [ISO]
- regulation of protein kinase A signaling [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- regulation of synaptic vesicle exocytosis [ISO]
- response to oxidative stress [ISO]
- tangential migration from the subventricular zone to the olfactory bulb [ISO]
Gene Ontology Molecular Function- GTP binding [ISO]
- GTP-dependent protein kinase activity [ISO]
- GTPase activator activity [ISO]
- GTPase activity [ISO]
- MAP kinase kinase activity [ISO]
- Rho GTPase binding [ISO]
- SNARE binding [ISO]
- actin binding [ISO]
- clathrin binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- kinase activity [ISO, ISS]
- peroxidase inhibitor activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- syntaxin-1 binding [ISO]
- tubulin binding [ISO]
- GTP binding [ISO]
- GTP-dependent protein kinase activity [ISO]
- GTPase activator activity [ISO]
- GTPase activity [ISO]
- MAP kinase kinase activity [ISO]
- Rho GTPase binding [ISO]
- SNARE binding [ISO]
- actin binding [ISO]
- clathrin binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- kinase activity [ISO, ISS]
- peroxidase inhibitor activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- syntaxin-1 binding [ISO]
- tubulin binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- axon [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of mitochondrial outer membrane [ISO]
- cytoplasmic vesicle [ISO, ISS]
- cytosol [ISO]
- dendrite [IDA, ISO]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [ISO, ISS]
- endosome [ISO, ISS]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- inclusion body [ISO]
- intracellular membrane-bounded organelle [IDA]
- lysosome [ISO, ISS]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrial inner membrane [ISO, ISS]
- mitochondrial matrix [ISO, ISS]
- mitochondrial membrane [ISO]
- mitochondrial outer membrane [ISO, ISS]
- mitochondrion [ISO]
- neuron projection [IDA, ISO]
- neuronal cell body [ISO]
- perikaryon [IDA, ISO]
- plasma membrane [ISO]
- synapse [ISO]
- synaptic vesicle [ISO]
- trans-Golgi network [ISO]
Download Curated Data for this Protein
256475
10116
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- Interactors 3
- Interactions 4
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