Rattus norvegicus
TRAF6
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
GO Process (44)
GO Function (11)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [ISO]
- JNK cascade [IMP]
- T cell receptor signaling pathway [ISO]
- T-helper 1 type immune response [ISO]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of protein kinase activity [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [ISO]
- bone remodeling [ISO]
- bone resorption [ISO]
- cell development [ISO]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [IMP]
- immune response [ISO]
- interleukin-1-mediated signaling pathway [IMP, ISO]
- myeloid dendritic cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [ISO]
- odontogenesis of dentin-containing tooth [ISO]
- organ morphogenesis [ISO]
- ossification [ISO]
- osteoclast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of interleukin-12 biosynthetic process [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [ISO]
- positive regulation of lipopolysaccharide-mediated signaling pathway [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein K63-linked ubiquitination [ISO, ISS]
- protein autoubiquitination [ISO]
- protein complex assembly [IMP]
- protein polyubiquitination [ISO]
- protein ubiquitination [ISO]
- regulation of immunoglobulin secretion [ISO]
- response to interleukin-1 [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS]
- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS]
Gene Ontology Cellular Component
Download Curated Data for this Protein
259875
10116
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- Interactors 10
- Interactions 15
- Network
- PTM Sites 1