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Saccharomyces cerevisiae (S288c)

LPD1

HPD1, dihydrolipoyl dehydrogenase, L000000951, YFL018C

Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication

GO Process (8)

GO Function (4)

GO Component (5)

Gene Ontology Biological Process

2-oxoglutarate metabolic process [IMP]

L-serine biosynthetic process [IMP]

glycine catabolic process [IMP]

hydrogen peroxide metabolic process [IGI, IMP]

isoleucine catabolic process [IMP]

leucine catabolic process [IMP]

pyruvate metabolic process [IMP]

valine catabolic process [IMP]

Gene Ontology Molecular Function

dihydrolipoyl dehydrogenase activity [IDA]
glycine dehydrogenase (decarboxylating) activity [IMP]
oxoglutarate dehydrogenase (succinyl-transferring) activity [IMP]
pyruvate dehydrogenase activity [IMP]

Gene Ontology Cellular Component

glycine cleavage complex [IMP]

mitochondrial nucleoid [IDA]

mitochondrial oxoglutarate dehydrogenase complex [IDA]

mitochondrial pyruvate dehydrogenase complex [IDA]

mitochondrion [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31128

559292

Interactors 493
Interactions 564
Network
PTM Sites 1