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Saccharomyces cerevisiae (S288c)

CDC45

SLD4, L000003380, YLR103C

DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes

GO Process (4)

GO Function (3)

GO Component (5)

Gene Ontology Biological Process

DNA replication initiation [IGI, IMP]

double-strand break repair via break-induced replication [IMP]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication [IPI]

regulation of chromatin silencing at telomere [IMP]

Gene Ontology Molecular Function

DNA replication origin binding [IDA]
chromatin binding [IDA]
single-stranded DNA binding [IDA, IMP]

Gene Ontology Cellular Component

DNA replication preinitiation complex [IDA]

nuclear pre-replicative complex [IDA]

nuclear replication fork [IDA]

replication fork protection complex [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31376

559292

Interactors 282
Interactions 633
Network
PTM Sites 4