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Saccharomyces cerevisiae (S288c)

SIR3

CMT1, MAR2, STE8, chromatin-silencing protein SIR3, L000001896, YLR442C

Silencing protein; interacts with Sir2p, Sir4p, and histone H3 and H4 tails to establish transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus (residues 840-978) assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; SIR3 has a paralog, ORC1, that arose from the whole genome duplication

GO Process (4)

GO Function (5)

GO Component (7)

Gene Ontology Biological Process

chromatin silencing at silent mating-type cassette [IGI, IMP]

heterochromatin assembly [IMP]

negative regulation of chromatin silencing involved in replicative cell aging [IDA]

nuclear-transcribed mRNA catabolic process, non-stop decay [IMP]

Gene Ontology Molecular Function

chromatin binding [IDA]
double-stranded DNA binding [IDA]
nucleosomal histone binding [IDA]
nucleosome binding [IDA]
single-stranded DNA binding [IDA]

Gene Ontology Cellular Component

chromatin silencing complex [IDA]

chromosome, telomeric region [IDA]

mitochondrion [IDA]

nuclear chromosome, telomeric region [IDA]

nuclear heterochromatin [IDA]

nuclear telomeric heterochromatin [IDA]

nucleolus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31701

559292

Interactors 131
Interactions 335
Network
PTM Sites 4