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Saccharomyces cerevisiae (S288c)

NTG1

FUN33, SCR1, ogg2, bifunctional N-glycosylase/AP lyase NTG1, L000004114, YAL015C

DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication

GO Process (5)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

DNA repair [IDA]

base-excision repair [IDA]

base-excision repair, AP site formation [IDA]

cellular response to oxidative stress [IMP]

positive regulation of mitochondrial DNA replication [IMP]

Gene Ontology Molecular Function

DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
oxidized purine nucleobase lesion DNA N-glycosylase activity [IDA]
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [IDA, ISS]

Gene Ontology Cellular Component

mitochondrion [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31751

559292

Interactors 114
Interactions 142
Network
PTM Sites 1