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Saccharomyces cerevisiae (S288c)

DBF4

DNA52, LSD7, protein serine/threonine kinase activating protein DBF4, L000000488, S000029149, L000000513, YDR052C

Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress

GO Process (5)

GO Function (2)

GO Component (4)

Gene Ontology Biological Process

DNA replication initiation [IPI]

negative regulation of exit from mitosis [IGI, IMP]

positive regulation of meiosis I [IMP]

positive regulation of protein kinase activity [IDA, IGI, IMP]

premeiotic DNA replication [IMP]

Gene Ontology Molecular Function

DNA replication origin binding [IDA]
protein serine/threonine kinase activator activity [IGI, IMP, IPI]

Gene Ontology Cellular Component

Dbf4-dependent protein kinase complex [IGI, IPI]

chromosome, centromeric region [IDA]

cytoplasm [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

32106

559292

Interactors 839
Interactions 1,221
Network
PTM Sites 43