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Saccharomyces cerevisiae (S288c)

DPB4

S000007463, YDR121W

Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization

GO Process (7)

GO Function (5)

GO Component (2)

Gene Ontology Biological Process

ATP-dependent chromatin remodeling [IDA]

DNA-dependent DNA replication [IDA, IMP]

error-prone translesion synthesis [IDA]

heterochromatin organization involved in chromatin silencing [IGI, IMP]

leading strand elongation [IGI, IMP]

nucleosome mobilization [IDA]

replicative senescence [IMP]

Gene Ontology Molecular Function

DNA-directed DNA polymerase activity [IDA, IMP]
chromatin DNA binding [IDA]
double-stranded DNA binding [IDA]
nucleosomal DNA binding [IDA]
single-stranded DNA binding [IDA]

Gene Ontology Cellular Component

CHRAC [IDA, IPI]

epsilon DNA polymerase complex [IDA, IPI]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

32177

559292

Interactors 161
Interactions 314
Network
PTM Sites 4