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Saccharomyces cerevisiae (S288c)

SYF1

NTC90, L000004195, YDR416W

Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans

GO Process (1)

GO Function (2)

GO Component (7)

Gene Ontology Biological Process

generation of catalytic spliceosome for first transesterification step [IDA]

Gene Ontology Molecular Function

first spliceosomal transesterification activity [IC]
second spliceosomal transesterification activity [IC]

Gene Ontology Cellular Component

Prp19 complex [IDA]

U2-type catalytic step 1 spliceosome [IDA]

U2-type catalytic step 2 spliceosome [IDA]

U2-type post-mRNA release spliceosomal complex [IDA]

U2-type prespliceosome [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

32475

559292

Interactors 266
Interactions 413
Network
PTM Sites 1