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Saccharomyces cerevisiae (S288c)

HOS2

RTL1, histone deacetylase HOS2, L000004092, L000003448, YGL194C

Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS

GO Process (5)

GO Function (2)

GO Component (4)

Gene Ontology Biological Process

chromatin organization [ISS]

histone deacetylation [IDA]

negative regulation of meiosis [IMP]

positive regulation of stress-activated MAPK cascade [IMP]

regulation of transcription, DNA-templated [IMP, ISS]

Gene Ontology Molecular Function

NAD-dependent histone deacetylase activity [IDA]
NAD-independent histone deacetylase activity [IDA]

Gene Ontology Cellular Component

Rpd3L-Expanded complex [IDA]

Set3 complex [IDA]

cytoplasm [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

33063

559292

Interactors 409
Interactions 713
Network