BioGRID COVID-19 Coronavirus Curation Project
Search BioGRID for SARS-CoV-2 Protein Interactions | Download SARS-CoV-2 and Coronavirus-Related Interactions

Saccharomyces cerevisiae (S288c)

GCN5

AAS104, ADA4, SWI9, histone acetyltransferase GCN5, KAT2, L000000684, YGR252W

Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation

GO Process (4)

GO Function (4)

GO Component (6)

Gene Ontology Biological Process

chromatin modification [IDA]

chromatin organization involved in regulation of transcription [IMP]

histone acetylation [IDA, IGI, IMP]

positive regulation of transcription elongation from RNA polymerase II promoter [IGI, IMP]

Gene Ontology Molecular Function

H3 histone acetyltransferase activity [IDA, IGI, IMP]
histone acetyltransferase activity [IDA]
lysine-acetylated histone binding [IDA]
transcription coactivator activity [TAS]

Gene Ontology Cellular Component

Ada2/Gcn5/Ada3 transcription activator complex [IDA, IPI]

SAGA complex [IDA]

SLIK (SAGA-like) complex [IDA]

chromosome, centromeric region [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

33503

559292

Interactors 658
Interactions 1,324
Network
PTM Sites 7