Saccharomyces cerevisiae (S288c)
HAM1
nucleoside triphosphate pyrophosphohydrolase HAM1, L000003233, YJR069C
Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimidines from deoxyribonucleoside triphosphate pools; functions together with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress
GO Process (2)
GO Function (10)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- GTP diphosphatase activity [IDA]
- ITP diphosphatase activity [IDA]
- UTP diphosphatase activity [IDA]
- XTP diphosphatase activity [IDA]
- dATP pyrophosphohydrolase activity [IDA]
- dCTP diphosphatase activity [IDA]
- dGTP diphosphatase activity [IDA]
- dITP diphosphatase activity [IDA]
- dTTP diphosphatase activity [IDA]
- dUTP diphosphatase activity [IDA]
- GTP diphosphatase activity [IDA]
- ITP diphosphatase activity [IDA]
- UTP diphosphatase activity [IDA]
- XTP diphosphatase activity [IDA]
- dATP pyrophosphohydrolase activity [IDA]
- dCTP diphosphatase activity [IDA]
- dGTP diphosphatase activity [IDA]
- dITP diphosphatase activity [IDA]
- dTTP diphosphatase activity [IDA]
- dUTP diphosphatase activity [IDA]
Download Curated Data for this Protein
33826
559292
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- Interactors 59
- Interactions 66
- Network
- PTM Sites 6