Saccharomyces cerevisiae (S288c)


DER3, E3 ubiquitin-protein ligase HRD1, L000002963, YOL013C
Ubiquitin-protein ligase; functions in ER retention of misfolded proteins; required for ER-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon

External Database Linkouts

SGD | Entrez Gene | RefSeq | UniprotKB | PhosphoGRID
Download 286 Published Interactions For This Protein
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  • Interactors (128)
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  • PTM Sites (2)