Saccharomyces cerevisiae (S288c)
HMG1
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1, L000000789, YML075C
HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication
GO Process (2)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
35066
559292
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- Interactors 250
- Interactions 332
- Network
- PTM Sites 16