Saccharomyces cerevisiae (S288c)

MLH1

PMS2, mismatch repair ATPase MLH1, L000001121, YMR167W

Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer

GO Process (4)

GO Function (7)

GO Component (7)

Gene Ontology Biological Process

meiotic heteroduplex formation [IMP]

meiotic mismatch repair [IMP]

mismatch repair [IMP]

reciprocal meiotic recombination [IMP]

Gene Ontology Molecular Function

ATP binding [IMP]
ATPase activity [IDA, IMP]
DNA insertion or deletion binding [IDA]
dinucleotide insertion or deletion binding [IDA]
double-stranded DNA binding [IDA]
heteroduplex DNA loop binding [IDA]
single-stranded DNA binding [IDA]

Gene Ontology Cellular Component

MutLalpha complex [IPI]

MutLgamma complex [IPI]

chiasma [IBA]

cytoplasm [IDA]

mitochondrion [IDA]

nucleus [IDA]

synaptonemal complex [IBA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

35345

559292

Interactors 239
Interactions 406
Network
PTM Sites 6

Result Summary

MLH1

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [IMP]ATPase activity [IDA, IMP]DNA insertion or deletion binding [IDA]dinucleotide insertion or deletion binding [IDA]double-stranded DNA binding [IDA]heteroduplex DNA loop binding [IDA]single-stranded DNA binding [IDA]

Gene Ontology Cellular Component

ATP binding [IMP]
ATPase activity [IDA, IMP]
DNA insertion or deletion binding [IDA]
dinucleotide insertion or deletion binding [IDA]
double-stranded DNA binding [IDA]
heteroduplex DNA loop binding [IDA]
single-stranded DNA binding [IDA]