Saccharomyces cerevisiae (S288c)
RPH1
KDM4, L000004504, YER169W
JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNAP II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; target of stess-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
GO Process (2)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- histone demethylase activity (H3-K36 specific) [IDA, IMP]
- histone demethylase activity (H3-K9 specific) [IDA]
- sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- histone demethylase activity (H3-K36 specific) [IDA, IMP]
- histone demethylase activity (H3-K9 specific) [IDA]
- sequence-specific DNA binding [IDA, IMP]
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- Interactors 148
- Interactions 165
- Network
- PTM Sites 22