CELE_F55F8.4, tag-326, F55F8.4

cir-1 is a nuclear protein homologous to mammalian CIR, a component of the co-repressor complex which associates with CBF1 in mammals (OMIM:605228); cir-1 is required for larval and different aspects of germ line development from proliferation and gonad extension, to progression of meiosis; cir-1 mutants cause 90% of larvae to cease development at larval stage1, escapers are lethargic and show defects in nucleolar morphology; cir-1 RNAi results into 100% embryonic lethality indicating that cir-1 is required maternally for embryonic development and zygotically for later stages of development for robust germline proliferation, oogenesis and vulval formation; CIR-1, MOG-3 and MEP-1 belong to single complex; CIR-1 expression coincides with mog-3::GFP; similar to MOG-3, CIR-1 is detected in somatic and meiotic nuclei as well as developing L4 vulva.

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