Caenorhabditis elegans
PDI-3
CELE_H06O01.1, H06O01.1
pdi-3 encodes a protein disulfide isomerase (PDI) required for normal cuticle collagen deposition and, subliminally, for maintenance of normal body shape; PDI-3 has both PDI and calcium-dependent transglutaminase activity in vitro, crosslinking proteins through a gamma-glutamyl epsilon-lysine dual residue; PDI-3 is homologous to the human PDI ERp60, as well as a homolog in the dog heartworm Dirofilaria immitis that is required for larval molting; the joint PDI/transglutaminase activity of PDI-3 is biochemically conserved in nematodes and mammals; pdi-3 is constitutively and broadly expressed, particularly in gut and hypodermis.
GO Process (12)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- body morphogenesis [IGI, IMP]
- collagen and cuticulin-based cuticle development [IGI, IMP]
- nematode male tail tip morphogenesis [IGI]
- oviposition [IGI]
- peptide cross-linking [IDA]
- positive regulation of embryonic development [IGI]
- positive regulation of multicellular organism growth [IMP]
- post-anal tail morphogenesis [IGI]
- protein deglutathionylation [IDA]
- protein folding [IDA]
- regulation of cell shape [IGI]
- response to endoplasmic reticulum stress [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
37878
6239
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- Interactors 14
- Interactions 15
- Network